Online MBSR Program for Cancer Survivors With Chronic Neuropathic Pain

Titre officiel

The Effects of an Online Mindfulness-Based Stress Reduction (MBSR) Program on Quality of Life and Immune Function Among Cancer Survivors With Chronic Neuropathic Pain

Sommaire:

Cet essai à répartition aléatoire contrôlé a pour objet d'évaluer l'efficacité d'une approche interdisciplinaire de traitement associant la gestion médicale au programme de réduction du stress basée sur la pleine conscience (RSPC) en réduisant l’invalidité et en améliorant la qualité de vie des survivants d’un cancer qui souffrent de douleurs neuropathiques chroniques graves.

Description de l'essai

Primary Outcome:

  • Change from baseline in pain-related disability, as measured by the Brief Pain Inventory - Pain Interference scale, at 3-month post-intervention.
Secondary Outcome:
  • Change from baseline in pain severity, as measured by the Brief Pain Inventory - Pain Severity scale, at 3 months post-intervention
  • Change from baseline in mood states, as measured by the Profile of Mood States scale, at 3 months post-intervention
  • Overall change in status from baseline, as measured by Patient Global Impression of Change scale, at 3 months post-intervention
  • Change from baseline in depressive symptoms, as measured by the Patient Health Questionnaire - 9 scale, at 3 months post-intervention
  • Change from baseline in pain catastrophizing, as measured by the Pain Catastrophizing Scale, at 3 months post-intervention.
  • Change from baseline in mindfulness, as measured by the Five Facet Mindfulness Questionnaire, at 3 months post-intervention.
  • Change from baseline in quality of life, as measured by the Functional Assessment of Cancer Therapy - General, at 3 months post-intervention.
  • Change from baseline in fatigue, as measured by the Brief Fatigue Inventory, at 3 months post-intervention.
  • Change from baseline in fear of cancer recurrence, as measured by the Fear of Cancer Recurrence Inventory, at 3 months post-intervention.
  • Change from baseline in immune function, as measured by blood levels of tumour necrosis factor - alpha interleukin-6, interleukin-4, interleukin-10, and c-reactive protein at 3 months post-intervention.
Chronic neuropathic pain (CNP) affects close to 50% of cancer survivors. Even with the best medical treatment, some survivors continue to experience disabling pain. In our recent survey with cancer survivors, we found that the capacity to be aware of different aspects of one's day-to-day experiences, without judgment or reactivity (i.e., being mindful) predicted decreased pain intensity, pain related disability, and increased health-related quality of life among cancer survivors with CNP. Building on these findings, the present randomized controlled trial will evaluate the effectiveness of an online Mindfulness-Based Stress Reduction (MBSR) program for cancer survivors with moderate to severe CNP. The program will benefit patients in rural and remote regions and patients with mobility issues. We will recruit 100 cancer survivors. All will have their medical treatment optimized by a pain specialist. Additionally, they will complete an 8-week online MBSR program. We hypothesize that the online MBSR program will result in less pain perception, better function and increased health-related quality of life. We will also examine the effects of the MBSR training on biomarkers of stress and immune function.

Voir cet essai sur ClinicalTrials.gov

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Ressources

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