Exercise for Rectal Cancer Patients Undergoing Preoperative Neoadjuvant Chemoradiation

Official Title

Safety and Feasibility of an Exercise Intervention for Adults Undergoing Preoperative Neoadjuvant Chemoradiation for Rectal Cancer

Summary:

Currently, there is no clear indication if exercise is safe and if it confers health benefits for adults undergoing preoperative neoadjuvant chemoradiation for rectal cancer - a population who may have limited exercise tolerance and who may be at an increased risk for adverse events associated with exercise. In this prospective single-arm feasibility trial, we aim to examine the safety and feasibility of a 12-week exercise intervention for adults undergoing preoperative neoadjuvant chemoradiation for rectal cancer to inform the development of a large-scale randomized controlled trial that will assess the efficacy of exercise administered during preoperative neoadjuvant chemoradiation for rectal cancer. Adults diagnosed with rectal cancer and scheduled for preoperative neoadjuvant chemoradiation will be recruited over a 12-month period into a supervised exercise intervention consisting of aerobic and strength training to be done 3 times per week. Feasibility, safety, patient-reported outcomes, and physical tests will be performed pre-intervention and post-intervention. This study will provide data on the feasibility of an exercise intervention and will help determine if it is safe to progress with a large-scale randomized controlled trial to test the benefits of exercise for adults undergoing preoperative neoadjuvant chemoradiation for rectal cancer. It will also provide initial estimates of the parameters for patient-reported outcomes, which are required to calculate the sample size for the large-scale randomized controlled trial to ensure it is sufficiently powered.

Trial Description

Primary Outcome:

  • Recruitment Rates
  • Retention Rates
  • Adherence Rates
  • Number of Participants with Adverse Events

View this trial on ClinicalTrials.gov

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Resources

Canadian Cancer Society

These resources are provided in partnership with the Canadian Cancer Society