Multi-Modality Radiation Treatment Planning for Malignant Glioma

Titre officiel

A Phase I Multi-Modality Radiation Treatment Planning for Malignant Glioma

Sommaire:

Cette étude a pour but de détecter des sous-volumes tumoraux potentiellement significatifs sur le plan biologique d’après l’imagerie du métabolisme de la tumeur (tomographie par émission de positons [TEP]), l’irrigation sanguine de la tumeur (tomodensitométrie [TDM] dynamique) et l’hypoxie tumorale (TEP + TDM dynamique).

Description de l'essai

Primary Objective:

• To identify potentially biologically significant tumour sub-volumes based on imaging of tumour metabolism (PET), tumour perfusion (dynamic CT) and tumour hypoxia (PET + dynamic CT)

Summary of events:

Study enrollment

• Post-op contrast enhanced diagnostic MRI no more than 12 weeks of treatment planning CT

• EPT-CT and Dynamic Contrast Enhanced CT (electronic fusion of the anatomic (MRI & Treatment Planning CT) and biologic (PET-CT and Dynamic Contrast Enhanced CT) image sets to determine biologic tumour volumes for comparison to failure sites)
  

Radiation Treatment Planning CT

• Electronic fusion of the anatomic image sets (MRI and Treatment Planning CT) to determine standard tumour volumes to be used for radiation planning and delivery
  

Radiation Treatment

• Contrast Enhanced Diagnostic MRI at the time of tumour recurrence
• Fusion of the MRI at recurrence to the initial standard and biologic tumour volumes
• Correlation of the image set from the MRI at recurrence with the initial standard and biologic image sets to determine which initial tumour volumes or set of tumour volumes best correlates with tumour recurrence